Genetic Conditions & Biochemical Sensitivities

Genetic conditions and biochemical sensitivities involve inheritable genetic variations (SNPs) like MTHFR, COMT, and others that affect methylation, detoxification, and histamine breakdown. These genetic terrains can predispose individuals to chronic illness, Mast Cell Activation Syndrome (MCAS), hypermobility (hEDS), and hyper-reactivity to environmental triggers.

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Common Symptoms

Histamine intolerance (flushing, hives, headaches)

Adverse reactions to supplements or medications

Chronic fatigue and brain fog

Chemical and environmental sensitivities

Anxiety, mood swings, and nervous system dysregulation

Causes & Triggers

Genetic SNPs (MTHFR, COMT, DAO, MAO-A)
Environmental toxins overloading detox pathways
Nutrient deficiencies impacting methylation
Chronic stress and limbic system dysfunction

Diagnosis

Diagnosis typically involves genetic testing (e.g., whole genome sequencing or specific SNP panels) combined with functional lab testing to assess methylation, organic acids, and histamine levels.

Treatment Approaches

Targeted nutritional support (e.g., methylated B vitamins, depending on tolerance)

Low histamine diet and DAO enzyme supplementation

Gentle detoxification protocols

Nervous system regulation and limbic retraining

Addressing co-occurring conditions like MCAS or hEDS

Not Sure Where to Start?

Take our free Root Cause Assessment to help identify whether your symptoms are primarily driven by genetics, environmental toxins, or nervous system dysregulation.

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